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Pharmacogenomics · Drug Safety
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Medication Decisions

Upload your VCF file and instantly assess drug safety, dosage adjustments, and toxicity risks using CPIC-aligned pharmacogenomic analysis — tailored to your unique genetic profile.

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Analysis Tool

Pharmacogenomic Risk Analyzer

Upload your VCF file and select medications to receive personalized risk predictions.

01

Upload VCF File

Variant Call Format v4.2

Drag & drop your VCF file here

or click to browse files

.vcf onlyMax 5 MB
02

Select Drug(s)

Choose quick-select options or search below

VCF file required
Drugs required
Process

How GenomeGuard Works

From raw genomic data to clinically actionable insights in seconds.

01

Upload VCF File

Drag & drop or browse your Variant Call Format (.vcf) file. We validate structure, check for required INFO tags (GENE, STAR, RS), and parse pharmacogenomic variants.

Supports VCF v4.2 • Up to 5 MB
02

Select Drug(s)

Choose from supported drugs including Codeine, Warfarin, Clopidogrel, Simvastatin, Tacrolimus, and Isoniazid — or enter a custom drug name.

Single drug or comma-separated list
03

Get Analysis

It analyzes your variants across 20 critical pharmacogenes, predicts risk levels, and generates clinical explanations with specific variant citations.

Color-coded risk • CPIC recommendations

Risk Classification

Safe— No dose adjustment needed
Adjust Dosage— Modified dosing recommended
Toxic— Risk of serious toxicity
Ineffective— Drug may not work
Unknown— Insufficient data
Features
Everything You Need,
All in One Place
Core Feature

Genomic Analysis

Upload your VCF file and get instant pharmacogenomic risk assessments across 20 genes — powered by CPIC guidelines.

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Family Planning

IVF & Genetic Compatibility

See how your genetics combine with your partner's to predict medication responses for your future children.

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Scanner

Pill Scanner

Snap a photo of any medication and instantly identify pharmacogenomic risks based on your genetic profile.

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Analysis

Drug Interaction Checker

Analyze how your body processes 45+ common drugs including Warfarin, Codeine, Clopidogrel, and Simvastatin.

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Reference

Drug Safety Matrix

Explore a comprehensive gene-drug safety grid showing risk levels for every phenotype-drug combination at a glance.

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Drug–Gene Interactions

Key pharmacogenomic relationships analyzed by GenomeGuard

  • Prodrug → morphine conversion — Toxic if ultrarapid metabolizer

    CODEINECYP2D6

  • Clearance and target sensitivity — Bleeding if poor metabolizer/sensitive

    WARFARINCYP2C9 + VKORC1

  • Prodrug activation — Ineffective if poor metabolizer

    CLOPIDOGRELCYP2C19

  • Hepatic uptake — Myopathy if *5 variant

    SIMVASTATINSLCO1B1

  • Thiopurine inactivation — Myelosuppression if deficient

    AZATHIOPRINETPMT + NUDT15

  • 5-FU catabolism — Severe toxicity if DPYD deficient

    FLUOROURACILDPYD

  • Immunosuppressant clearance — Dose increase if expresser

    TACROLIMUSCYP3A5

  • Hepatic acetylation rate — Hepatotoxicity if slow acetylator

    ISONIAZIDNAT2

  • Severe cutaneous reactions — SJS/SCAR if *58:01 carrier

    ALLOPURINOLHLA-B

  • Red blood cell oxidative stress — Hemolysis if G6PD deficient

    PRIMAQUINEG6PD

  • Red blood cell oxidative stress — Hemolysis if G6PD deficient

    PRIMAQUINEG6PD

  • Severe cutaneous reactions — SJS/SCAR if *58:01 carrier

    ALLOPURINOLHLA-B

  • Hepatic acetylation rate — Hepatotoxicity if slow acetylator

    ISONIAZIDNAT2

  • Immunosuppressant clearance — Dose increase if expresser

    TACROLIMUSCYP3A5

  • 5-FU catabolism — Severe toxicity if DPYD deficient

    FLUOROURACILDPYD

  • Thiopurine inactivation — Myelosuppression if deficient

    AZATHIOPRINETPMT + NUDT15

  • Hepatic uptake — Myopathy if *5 variant

    SIMVASTATINSLCO1B1

  • Prodrug activation — Ineffective if poor metabolizer

    CLOPIDOGRELCYP2C19

  • Clearance and target sensitivity — Bleeding if poor metabolizer/sensitive

    WARFARINCYP2C9 + VKORC1

  • Prodrug → morphine conversion — Toxic if ultrarapid metabolizer

    CODEINECYP2D6

Genes & Drugs Covered

CYP2D6

Cytochrome P450 2D6

Metabolizes ~25% of all clinical drugs

Key Drugs

CodeineTramadolTamoxifenMetoprolol

Common Variants

*1*2*4*5*10*17*41

CYP2C19

Cytochrome P450 2C19

Key in prodrug activation and PPI clearance

Key Drugs

ClopidogrelPantoprazoleSertralineAmitriptyline

Common Variants

*1*2*3*17

CYP2C9

Cytochrome P450 2C9

Metabolizes narrow therapeutic index drugs

Key Drugs

WarfarinCelecoxibPhenytoinLosartan

Common Variants

*1*2*3*5*6

SLCO1B1

Solute Carrier Organic Anion Transporter 1B1

Mediates hepatic statin uptake

Key Drugs

SimvastatinAtorvastatinRosuvastatin

Common Variants

*1*5*15*17

TPMT

Thiopurine S-Methyltransferase

Clears thiopurines; prevents myelosuppression

Key Drugs

Azathioprine6-MercaptopurineThioguanine

Common Variants

*1*2*3A*3B*3C

DPYD

Dihydropyrimidine Dehydrogenase

Rate-limiting step in fluoropyrimidine catabolism

Key Drugs

Fluorouracil (5-FU)CapecitabineTegafur

Common Variants

*1*2AHapB3c.2846A>T

CYP3A5

Cytochrome P450 3A5

Tacrolimus dosing and clearance; key in transplant

Key Drugs

Tacrolimus

Common Variants

*1*3*6*7

NAT2

N-Acetyltransferase 2

Isoniazid (anti-TB) acetylation rate & hepatotoxicity

Key Drugs

Isoniazid

Common Variants

*4*5A*5B*6A*7A

HLA-B

Human Leukocyte Antigen B

SJS/SCAR immune-mediated hypersensitivity

Key Drugs

CarbamazepineAllopurinolPhenytoin

Common Variants

*15:02*58:01*57:01

G6PD

Glucose-6-Phosphate Dehydrogenase

Protects RBCs; deficiency causes drug-induced hemolysis

Key Drugs

PrimaquineRasburicase

Common Variants

BA-MediterraneanKerala-Kalyan

VKORC1

Vitamin K Epoxide Reductase Complex 1

Target of warfarin; determines warfarin sensitivity

Key Drugs

Warfarin

Common Variants

-1639G>A_AA-1639G>A_GA-1639G>A_GG

UGT1A1

UDP-Glucuronosyltransferase 1A1

Irinotecan clearance; prevents severe diarrhea & neutropenia

Key Drugs

IrinotecanAtazanavirMycophenolate

Common Variants

*1*6*28*36*37

Start Your Pharmacogenomic Journey

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20
Genes Covered
45+
Drugs Analyzed
<30s
Report Time

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GenomeGuard

AI-powered pharmacogenomic risk analysis. Helping clinicians and researchers make safer, personalised medication decisions.

Research Use Only

Resources

  • CPIC Guidelines
  • PharmGKB
  • VCF Format Spec
  • dbSNP

Genes

CYP2D6CYP2C19CYP2C9CYP3A5SLCO1B1TPMT
DPYDNAT2HLA-BG6PDVKORC1UGT1A1

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